SJFα是一种含13个原子连接桥的PROTAC。SJFα降解p38α，DC50为7.16nM，但降解p38δ效果较差(DC50=299nM)，且在浓度高达2.5μM时也不会降解其他p38亚型(β和γ)。
货号:ajcx12926
CAS:2254609-27-1
分子式:C59H67F2N7O11S
分子量：1120.27
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SJFα is a 13-atom linker PROTAC. SJFα degrades p38α with a DC50 of 7.16 nM, but is far less effective at degrading p38δ (DC50=299 nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5 µM[1].

[1]. Smith BE, et al. Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nat Commun. 2019 Jan 10;10(1):131.