ARRY-382是一种有效的，可口服的选择性CSF1R/c-Fms抑制剂，IC50为9nM。ARRY-382可用于晚期或转移性癌症的研究。
货号:ajcx30196
CAS:1313407-95-2
分子式:C32H36N8O2
分子量：564.68
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

ARRY-382 is a potent, oral and highly selective inhibitor of CSF1R/c-Fms with an IC50 of 9 nM. ARRY-382 can be used for the research of advanced or metastatic cancers[1].

ARRY-382 (1 µM) dramatically decreases the number of nurse-like cells (NLCs) compared to untreated cells[1].

[1]. David K Edwards V, et al. Targeting of colony-stimulating factor 1 receptor (CSF1R) in the CLL microenvironment yields antineoplastic activity in primary patient samples. Oncotarget. 2018 May 15;9(37):24576-24589.