BAY2416964是一种有效的,口服活性的芳基烃受体(AHR)拮抗剂，其IC50为341nM，可用于实体瘤的研究。详细信息请参考专利文献WO2018146010A1中的化合物192。
货号:ajcx30234
CAS:2242464-44-2
分子式:C18H18ClN5O3
分子量：387.82
溶解度:DMSO: 250 mg/mL (644.63 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

BAY 2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 192, has an IC50 of 341 nM. BAY 2416964 has the potential for solid tumors treatment[1].

BAY 2416964 (Example 192) induces AHR-regulated gene CYP1A1 expression in a human monocytic U937 cells with an IC50 of 4.3 nM[1].

[1]. Ilona GUTCHER, et al. 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamides for the treatment of cancer. WO2018146010A1