N4-Acetylcytidine triphosphate sodium 是一种内源性核苷代谢物，源于 tRNA 的降解，可通过诱导 HMGB1 的表达，启动和激活 NLRP3 炎症。
货号:ajcx14022
CAS:N/A
分子式:C11H14N3Na4O15P3
分子量：613.12
溶解度:H2O: ≥ 250 mg/mL (407.75 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

N4-Acetylcytidine triphosphate sodium is a endogenous nucleoside metabolite from the degradation of tRNA, primes and activates NLRP3 inflammation by inducing HMGB1 expression[1]. NLRP3 Human Endogenous Metabolite

N4-Acetylcytidine (0.3? mM or 1.0? mM) upregulates NF-κB and NLRP3 expression BV2 microglia, and this calls for HMGB1 expression and release[1].

[1]. Duan J, et al. N4-acetylcytidine is required for sustained NLRP3 inflammasome activation via HMGB1 pathway in microglia. Cell Signal. 2019 Jun;58:44-52.