Lalistat 1 is an inhibitor of lysosomal acid lipase (LAL; IC50 = 68 nM using purified human LAL).
CAS：501104-16-1
分子式：C12H18N4O3S
分子量：298.4
纯度：98%
存储：Store at -20°C

Background:

Lalistat 1 is an inhibitor of lysosomal acid lipase (LAL; IC50 = 68 nM using purified human LAL). It is selective for LAL over human pancreatic and bovine milk lipoprotein lipases up to a concentration of 10 µM. Lalistat 1 (0.01-10 µM) reduces cholesterol accumulation in lysosome-like storage organelles in GM03123 human fibroblast cells deficient in NPC1, a membrane protein found in late endosomes, in a concentration-dependent manner but has little effect on cholesterol accumulation in NPC1-deficient CHO cells.