H4Receptorantagonist1是一种有效的、有选择性的组胺H4受体(H4R)的反向激动剂，其IC50值为19nM。
CAS：848217-00-5
分子式：C16H17ClN4O
分子量：316.79
纯度：98%
存储：Store at -20°C

Background:

H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist, with an IC50 of 19 nM.

H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist, with an IC50 of 19 nM[1].

H4 Receptor antagonist 1 indicates that metabolic stability in rat microsomes is very low with only 1% parent compound remaining after 10 min incubation[1].

[1]. Cramp S, et al. Identification and hit-to-lead exploration of a novel series of histamine H4 receptor inverse agonists. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2516-9.