Background:

Doxofylline is an antagonist of adenosine A1 receptor which also inhibits phosphodiesterase IV.

参考文献:
[1]. Shukla D, et al. Doxofylline: a promising methylxanthine derivative for the treatment of asthma and chronic obstructive pulmonary disease. Expert Opin Pharmacother. 2009 Oct;10(14):2343-56.