INT-777 R-enantiomer 是 INT-77 的 R 型异构体，对 TGR5 的 EC50 值为 4.79 μM，活性比 INT-777 低。
CAS：1198786-98-9
分子式：C27H46O5
分子量：450.65
纯度：98%
存储：Store at -20°C

Background:

INT-777 (R-enantiomer) is the R-enantiomer of INT-777, with EC50 of 4.79 μM for TGR5, and less potent than INT-777.

INT-777 (R-enantiomer) is more choleretic than CA (4), but less than INT-777[1].

[1]. Pellicciari R, et al. Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity. J Med Chem. 2009 Dec 24;52(24):7958-61.