GSK467是一种有效选择性的KDM5(也称JARID1)抑制剂，ki值为10nM，是KDM4C选择性的180倍，而对KDM6或其他Jumonji家族成员没有明显的抑制作用。
CAS：1628332-52-4
分子式：C17H13N5O2
分子量：319.32
纯度：98%
存储：Store at -20°C

Background:

GSK467 is a selective KDM5 (JARID1) inhibitor with a ki of 10 nM for KDM5B, shows 180-fold selectivity for KDM4C and no measurable inhibitory effects toward KDM6 or other Jumonji family members[1]. ki: 10 nM (KDM5B)[1]

[1]. Johansson C, et al. Structural analysis of human KDM5B guides histone demethylase inhibitor development. Nat Chem Biol. 2016 Jul;12(7):539-45.