Prostaglandin A2 (PGA2) is a naturally occurring PG in gorgonian corals where it may function in self defense.
CAS：31753-19-2
分子式：C21H32O4
分子量：348.5
纯度：98%
存储：Store at -20°C

Background:

Prostaglandin A2 (PGA2) is a naturally occurring PG in gorgonian corals where it may function in self defense. At a 25 µM concentration, PGA2 blocks the cell cycle progression of NIH 3T3 cells at G1 and G2/M by preventing activation of cyclin-dependent kinases. At similar concentrations, it stabilizes transcripts for the tumor suppressor SMAR1, downregulating cyclin D1 expression. PGA2 also induces apoptosis in HL-60 cells. Prostaglandin A2 methyl ester is a lipophilic analog of PGA2 which may be more amenable for certain formulations or applications. Its biological properties have not been evaluated.