Bevenopran是一种外周μ阿片受体(μ-opioidreceptor)拮抗剂。
CAS：676500-67-7
分子式：C20H26N4O4
分子量：386.44
纯度：98%
存储：Store at -20°C

Background:

Bevenopran is a peripheral μ-opioid receptor antagonist.

Bevenopran is a peripheral μ-opioid receptor antagonist. Bevenopran is currently under investigation for the treatment of opioid-induced bowel dysfunction (OBD)[1]. Bevenopran tends to increase bowel movement (BM) frequency, especially for 0.1 mg twice daily and 4 mg daily, respectively[1].

[1]. Diego L, et al. Novel opioid antagonists for opioid-induced bowel dysfunction. Expert Opin Investig Drugs. 2011 Aug;20(8):1047-56. [2]. Siemens W, et al. Advances in pharmacotherapy for opioid-induced constipation - a systematic review. Expert Opin Pharmacother. 2015 Mar;16(4):515-32.