LXRβ agonist-2 是一种高效 β 选择性肝 X 受体 (LXRβ) 激动剂，EC50为 7 nM，其选择性是 LXRα (EC50=200 nM) 的 28.5 倍，用于治疗动脉粥样硬化。
CAS：1949801-52-8
分子式：C32H31F6N3O7
分子量：683.59
纯度：98%
存储：Store at -20°C

Background:

LXRβ agonist-2 is a highly potent and β-selective liver X receptor (LXRβ) agonist with EC50 of 7 nM, displays 28.5-fold selectivity over LXRα (EC50=200 nM) and used in the treatment of atherosclerosis[1]. EC50: 7 nM (LXRβ), 200 nM (LXRα)[1]

[1]. Koura M,et al. Discovery of a 2-hydroxyacetophenone derivative as an outstanding linker to enhance potency and β-selectivity of liver X receptor agonist. Bioorg Med Chem. 2016 Aug 15;24(16):3436-46.