QM385 是一种有效的降血糖素还原酶 (SPR) 抑制剂，IC50 值为 1.49 nM，并以纳摩尔效力和良好的口服生物利用度阻止 T 细胞增殖和自身免疫。
CAS：2296727-52-9
分子式：C18H19F3N6O2
分子量：408.38
纯度：98%
存储：Store at -20°C

Background:

QM385 is a potent sepiapterin reductase (SPR) inhibitor with an IC50 of 1.49 nM, which blocks T-cell proliferation and autoimmunity at nanomolar potency and with good oral bioavailability[1]. IC50: 1.49 nM (Sepiapterin reductase)[1]

QM385 effectively inhibits the proliferation of human CD4+ T cells at low doses[1].

[1]. Cronin SJF, et al. The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature. 2018 Nov;563(7732):564-568.