DSM265是一个PfDHODH抑制剂，其IC50值为8.9nM。DSM265还可以抑制恶性疟原虫3D7的生长，其EC50值为4.3nM。
CAS：1282041-94-4
分子式：C14H12F7N5S
分子量：415.33
纯度：98%
存储：Store at -20°C

Background:

DSM265 is a PfDHODH inhibitor with an IC50 of 8.9 nM. DSM265 can also inhibit the growth of P. falciparum 3D7 parasites with an EC50 of 4.3 nM.

[1]. Kokkonda S, et al. Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparumDihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity. J Med Chem. 2016 Jun 9;59(11):5416-31.