VU0650786是有效的、选择性的、能透过中枢神经系统的，谷氨酸受体亚型3(mGlu3)的负变构调节剂，IC50值为392nM。VU0650786在啮齿动物中具有抗抑郁和抗焦虑活性。
CAS：1809085-30-0
分子式：C18H15ClFN5O2
分子量：387.8
纯度：98%
存储：Store at -20°C

Background:

VU0650786 is a potent and selective CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3), with an IC50 of 392 nM. VU0650786 has antidepressant and anxiolytic activity in rodents[1]. mGluR3|392 nM (IC50)

[1]. Engers JL, et al. Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents. J Med Chem. 2015 Sep 24;58(18):7485-500.