Mardepodect (PF-2545920) 是一种有效的选择性 PDE10A 抑制剂，IC50 为 0.37 nM，比作用于其他 PDE 选择性高 1000 多倍。
CAS：898562-94-2
分子式：C25H20N4O
分子量：392.45
纯度：98%
存储：Store at -20°C

Background:

Mardepodect (PF-2545920) is a potent and selective PDE10A inhibitor with an IC50 of 0.37 nM, with >1000-fold selectivity over the PDE.

[1]. Verhoest PR, et al. Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the treatment of schizophrenia. J Med Chem, 2009, 52(16), 5188-5196. [2]. Grauer SM, et al. Phosphodiesterase 10A inhibitor activity in preclinical models of the positive, cognitive, and negative symptoms of schizophrenia. J Pharmacol Exp Ther, 2009, 331(2), 574-590.