ML-309 is an inhibitor of mutant isocitrate dehydrogenase 1 (IDH1).
CAS：1355327-02-4
分子式：C29H29FN4O2.HCl
分子量：521
纯度：98%
存储：Store at -20°C

Background:

ML-309 is an inhibitor of mutant isocitrate dehydrogenase 1 (IDH1). It reversibly and selective inhibits IDH1R132H over wild-type IDH1 (IC50s = 96 and 36,500 nM, respectively). ML-309 reduces 2-hydroxyglutarate production in U87 MG glioblastoma cells (EC50 = 55 nM).