MPP+ is an active metabolite of MPTP , a neurotoxin used to cause selective destruction of dopaminergic neurons in animal models of parkinsonism.
CAS：36913-39-0
分子式：C12H12N.I
分子量：297.1
纯度：98%
存储：Store at -20°C

Background:

MPP+ is an active metabolite of MPTP , a neurotoxin used to cause selective destruction of dopaminergic neurons in animal models of parkinsonism. MPP+ induces neurotoxicity primarily by inhibiting complex I of the mitochondrial electron transport chain, resulting in ATP depletion and increased oxidative stress. The key features of different neurotoxic models of Parkinson’s disease, including the MPTP model, have been detailed.