KIN1400 is a small molecule activator of the RIG-1-like receptor (RLR) pathway that has antiviral activity.
CAS：446826-86-4
分子式：C24H17F2N3O2S
分子量：449.5
纯度：98%
存储：Store at -20°C

Background:

KIN1400 is a small molecule activator of the RIG-1-like receptor (RLR) pathway that has antiviral activity. It induces expression of the innate immune genes RIG-1, MDA5, IFIT1, IFIT2, IFITM1, OAS3, and Mx1 in THP-1 cells stimulated with phorbol 12-myristate 13-acetate . KIN1400 (20 μM) reduces West Nile and dengue viral RNA levels in HEK293 and Huh7 cells, respectively. It also inhibits hepatitis C virus (HCV) replication in a concentration-dependent manner in Huh7 cells.