Demethylwedelolactone (DWL) is a coumestan, originally isolated from E.
CAS：6468-55-9
分子式：C15H8O7
分子量：300.2
纯度：98%
存储：Store at -20°C

Background:

Demethylwedelolactone (DWL) is a coumestan, originally isolated from E. alba, with diverse biological activities. It reduces cytotoxicity induced by CCL4 and galactosamine in rat hepatocytes in a dose-dependent manner. DWL inhibits trypsin with an IC50 value of 3.0 μg/ml in vitro. It is the major constituent in purified butanolic extracts of E. prostrata which inhibit lethal and hemorrhagic activities of C. rhodostoma venom. DWL also inhibits anchorage-independent cell growth of MDA-MB-231 breast cancer cells and decreases the number of lung metastases in an MDA-MB-231 xenograft model in nude mice.