LNP023 是一种高效的补体因子 B (FB) 抑制剂，IC50 为 10 nM。LNP023 高亲和力地结合到 FB (KD =7.9 nM)。
CAS：1644670-37-0
分子式：C25H30N2O4
分子量：422.52
纯度：98%
存储：Store at -20°C

Background:

LNP023 is a highly potent factor B (FB) inhibitor with an IC50 value of 10 nM. LNP023 shows direct, reversible, and high-affinity binding to human FB (KD=7.9 nM)[1].

[1]. Schubart A, et al. Small-molecule factor B inhibitor for the treatment of complement-mediated diseases. Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7926-7931.