Tamoxifen is a selective estrogen receptor modulator that evokes tissue-dependent effects.
CAS：75504-34-6
分子式：C26H29NO2
分子量：387.5
纯度：98%
存储：Store at -20°C

Background:

Tamoxifen is a selective estrogen receptor modulator that evokes tissue-dependent effects. Tamoxifen N-oxide is a metabolite of tamoxifen that is produced by the action of flavin-containing monooxygenases. It can be converted back to tamoxifen by cytochrome P450 isoforms and hemoglobin. Like the parent compound, tamoxifen N-oxide can form DNA adducts. Tamoxifen N-oxide is a weak inhibitor of human hydroxysteroid sulfotransferase 2A1 (Kis = 9.1 and 16.9 µM for the sulfonation of dehydroepiandrosterone and pregnenolone, respectively).