ESI-05 (NSC 116966) 是一种特异性的 cAMP 直接激活交换蛋白 2 (EPAC2) 拮抗剂，IC50 值为 0.4 ?M，抑制 cAMP 诱导的 EPAC2 的活化，和 EAPC2 介导的 Rap1 的活化。
CAS：5184-64-5
分子式：C16H18O2S
分子量：274.38
纯度：98%
存储：Store at -20°C

Background:

ESI-05 (NSC 116966) is a specific antagonist of EPAC2 (exchange protein directly activated by cAMP 2), with an IC50 of 0.4 µM. ESI-05 (NSC 116966) inhibits cAMP-mediated activation of EPAC2 as well as EAPC2 mediated Rap1 activation[1]. IC50: 0.4 µM (EPAC2)[1]

[1]. Tsalkova T, et al. Isoform-specific antagonists of exchange proteins directly activated by cAMP. Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18613-8.