Biosynthesis of 12(R)-HETE in invertebrates is via lipoxygenation of arachidonic acid.
CAS：82337-46-0
分子式：C20H32O3
分子量：320.5
纯度：98%
存储：Store at -20°C

Background:

Biosynthesis of 12(R)-HETE in invertebrates is via lipoxygenation of arachidonic acid . In mammals, 12(R)-HETE can be produced by 12(R)-LOs and also by CYP450 oxidation. The activity of 12(R)-HETE in mammals is predominantly proinflammatory. 12(R)-HETE exhibits dose-dependent leukocyte chemotaxis at concentrations as low as 100 nM, and lowers intraocular pressure in rabbits.