Background:

D,L-3-Indolylglycine is an unnatural amino acid that is very similar to Tryptophan, with the indole moiety directly attached to the α-position. Target:D,L-3-Indolylglycine may be useful in the design of functional proteins. A study describes the inclusion of a similar aza-indoylglycine moiety in petidomimetics with the purpose of functionally replacing tryptophan moieties.