Daphnoretin is a coumarin that has been found in W.
CAS：2034-69-7
分子式：C19H12O7
分子量：352.3
纯度：98%
存储：Store at -20°C

Background:

Daphnoretin is a coumarin that has been found in W. indica and has diverse biological activities. It induces aggregation of washed rabbit platelets (EC50 = 17.2 μM), an effect that is reversed by the protein kinase C (PKC) inhibitor staurosporine . Daphnoretin is active against respiratory syncytial virus (RSV) in a plaque reduction assay using HEp-2 cells (IC50 = 5.87 μg/ml). It halts the cell cycle at the G2/M phase, induces apoptosis, and inhibits proliferation of human osteosarcoma (HOS) cells (IC50 = 3.89 μM). Daphnoretin also reduces proliferation, invasion, and migration of HCT116 colon cancer cells in a concentration-dependent manner.