SK1-IN-1是一种有效的鞘氨醇激酶1(SPHK1)抑制剂，IC50值为58nM。
CAS：1218816-71-7
分子式：C22H30N4O3
分子量：398.5
纯度：98%
存储：Store at -20°C

Background:

SK1-IN-1 is a potent sphingosine kinase 1 (SPHK1) inhibitor with an IC50 of 58 nM.

SK1-IN-1 demonstrates significant improvement in the intrinsic clearance, particularly against human liver microsomes. SK1-IN-1 is selected for rat PK studies and demonstrates modest in oral bioavailability with acceptable half-lives in blood circulation[1].

[1]. Xiang Y, et al. Discovery of novel sphingosine kinase-1 inhibitors. Part 2. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4550-4.