PZ-2891是一种可口服，能渗透血脑屏障的泛酸激酶(PANK)变构调节剂，乙酰辅酶A存在下,可起到正构抑制剂的作用(IC50=1.3nM,hPANK3)和PANK3变构活化作用。
CAS：2170608-82-7
分子式：C20H23N5O
分子量：349.43
纯度：98%
存储：Store at -20°C

Background:

PZ-2891 is an oral, allosteric, and brain penetrant pantothenate kinase (PANK) modulator, acting as both an orthosteric inhibitor (IC50=1.3 nM) and an allosteric activator of PANK3 activity in the presence of acetyl-CoA. IC50: 1.3 nM (PANK)[1]

[1]. Sharma LK, et al. A therapeutic approach to pantothenate kinase associated neurodegeneration. Nat Commun. 2018 Oct 23;9(1):4399.