FTI-276 是一种有效的 protein farnesyl transferase (PFT) 抑制剂, 作用于恶性疟原虫和人类的 IC50 值分别为 0.9 nM 和 0.5 nM。
CAS：1217471-51-6
分子式：C23H28F3N3O5S2
分子量：547.61
纯度：98%
存储：Store at -20°C

Background:

FTI-276 is a protein farnesyl transferase (PFT) inhibitor with IC50s of 0.9 nM and 0.5 nM for Plasmodium falciparum and human, respectively[1]. IC50: 0.9 nM (PFT, Plasmodium falciparum), 0.5 nM (PFT, human)[1].

[1]. Chakrabarti D, et al. Protein farnesyltransferase and protein prenylation in Plasmodium falciparum.J Biol Chem. 2002 Nov 1; 277(44):42066-73. Epub 2002 Aug 22.