GeA-69

GeA-69 is a selective, highly cell permeable allosteric inhibitor
CAS：2143475-98-1
分子式：C??H??N?O
分子量：300.35
纯度：98%
存储：Store at -20°C

Background:

GeA-69 is a selective, highly cell permeable allosteric inhibitor of poly-adenosine-diphosphate-ribose polymerase 14 (PARP14) targeting macrodomain 2, with a Kd of 2.1 μM[1].

Reference：
[1]. Schuller M, et al. Discovery of a Selective Allosteric Inhibitor Targeting Macrodomain 2 of Polyadenosine-Diphosphate-Ribose Polymerase 14. ACS Chem Biol. 2017 Nov 17;12(11):2866-2874.