| CAS NO: | 924416-43-3 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| Molecular Weight (MW) | 428.52 |
|---|---|
| Formula | C27H28N2O3 |
| CAS No. | 924416-43-3 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 86 mg/mL (200.7 mM) |
| Water: <1 mg/mL | |
| Ethanol: 50 mg/mL (116.7 mM) | |
| Other info | Chemical Name: 2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide InChi Key: SHHUPGSHGSNPDB-UHFFFAOYSA-N InChi Code: InChI=1S/C27H28N2O3/c30-26(28-24-15-17-29(18-16-24)19-21-7-3-1-4-8-21)20-32-25-13-11-23(12-14-25)27(31)22-9-5-2-6-10-22/h1-14,24H,15-20H2,(H,28,30) SMILES Code: O=C(C1=CC=C(OCC(NC2CCN(CC3=CC=CC=C3)CC2)=O)C=C1)C4=CC=CC=C4 |
| Synonyms | SC-396658; SC396658; SC 396658; |
| In Vitro | In vitro activity: AdipoRon increases AMPK activation, PGC-1α expression and mitochondrial biogenesis by binding to both AdipoR1 and AdipoR2 in C2C12 myotubes. Cell Assay: In C2C12 myotubes, AdipoRon increased PGC-1α expression and mitochondrial DNA content in a Ca2+- and dose-dependent way, |
|---|---|
| In Vivo | In skeletal muscle and liver of wild-type mice AdipoRon (50 mg/kg, i.v.) significantly induces phosphorylation of AMPK via AdipoR1 and AdipoR2. In WT mice, AdipoRon (50 mg/kg, p.o.) improves insulin resistance, glucose intolerance and dyslipidaemia by activating AdipoR1–AMPK–PGC-1α pathways in skeletal muscle, while by activating AdipoR2–PPAR-α pathways in the liver. Moreover, AdipoRon ameliorates diabetes of genetically obese rodent model db/db mice, and prolongs the shortened lifespan of db/db mice on a high-fat diet. |
| Animal model | Mice |
| Formulation & Dosage | 50 mg/kg, p.o. |
| References | Nature. 2013 Nov 28;503(7477):493-9. |
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