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EW-7197(Vactosertib)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
EW-7197(Vactosertib)图片
CAS NO:1352608-82-2
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
10mM * 1mL in DMSO电议

产品名称
EW7197
产品介绍

生物活性

EW-7197是一种高效,选择性可生物利用的TGF-βI受体ALK4/ALK5抑制剂,IC50分别为13 nM和11 nM。

Targets

TargetValue
ALK5IC50: 11nM
ALK4IC50: 13nM
ALK1IC50: >10μM
ALK2IC50: >10μM
ALK3IC50: >10μM
ALK6IC50: >10μM

化学数据

目录号A14213
作用机制Inhibitor (抑制剂)
M. Wt399.42
FormulaC22H18FN7
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1352608-82-2
SynonymsEW7197
SMILESCC1=CC=CC(=N1)C2=C(N=C(N2)CNC3=CC=CC=C3F)C4=CN5C(=NC=N5)C=C4

溶解度

In vitro (25°C)DMSO77 mg/mL (192.77 mM)
WaterInsoluble
Ethanol42 mg/mL (105.15 mM)
In vivo1%cmc-na9 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM25.04 mL125.18 mL250.36 mL
0.5 mM5.01 mL25.04 mL50.07 mL
1 mM2.5 mL12.52 mL25.04 mL
5 mM0.5 mL2.5 mL5.01 mL

*The above data is based on the productmolecular weight 399.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.