Milbemycin D is an insecticidal and anthelmintic antibiotic originally isolated from S.
CAS：77855-81-3
分子式：C33H48O7
分子量：556.7
纯度：98%
存储：Store at -20°C

Background:

Milbemycin D is an insecticidal and anthelmintic antibiotic originally isolated from S. hygroscopicus. It is toxic to third instar gypsy moth larvae with an LD50 value of 0.119 ug/g but not to sixth instar larvae. Milbemycin D eradicates A. caninum and is effective against T. canis in dogs when administered at doses of 0.05 and 0.1 mg/kg. It prevents D. immitis infection in dogs, but is not effective against T. vulpis or D. caninum. Milbemycin D also activates glutamate- (EC50 = 89 nM) and GABA-gated chloride channels.