C12 ceramide is a naturally occurring ceramide that is formed when C12 sphingomyelin is hydrolyzed by acid sphingomyelinase (ASM).
CAS：74713-60-3
分子式：C30H59NO3
分子量：481.8
纯度：98%
存储：Store at -20°C

Background:

C12 ceramide is a naturally occurring ceramide that is formed when C12 sphingomyelin is hydrolyzed by acid sphingomyelinase (ASM). It is a substrate for acid ceramidase, an enzyme that has 2- to 12-fold higher activity in fibroblasts from patients with Farber disease, a lipid storage disorder. C12 ceramide is found in the Wharton’s jelly, a protective coating that surrounds umbilical cord vessels, of babies born to women with pre-eclampsia. BODIPY C12 ceramide has been used to assess levels of ASM activity in plasma of patients with type A or B Niemann-Pick disease.