Spirohexenolide A is a metabolite originally isolated from S.
CAS：1193347-22-6
分子式：C25H28O5
分子量：408.5
纯度：98%
存储：Store at -20°C

Background:

Spirohexenolide A is a metabolite originally isolated from S. platensis. It inhibits growth in the NCI-60 cancer cell line panel (GI50s = 0.1-17 μM) with the RPMI-8226 multiple myeloma, HOP-92 lung, and SW620 colon cancer cell lines being most sensitive (GI50s = 254, 191, and 565 nM, respectively). Spirohexenolide A also binds to human macrophage migration inhibition factor (MIF; Kd = 35.9 μM) and inhibits MIF cellular uptake and lysosomal localization in HCT116 cells.