N1,N12-Acetylspermine is a diacetylated derivative of spermine, an endogenous polyamine synthesized from spermidine, that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine.
CAS：77928-71-3
分子式：C14H30N4O2.2HCl
分子量：359.3
纯度：98%
存储：Store at -20°C

Background:

N1,N12-Acetylspermine is a diacetylated derivative of spermine , an endogenous polyamine synthesized from spermidine , that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine. Spermine is required for eukaryotic cell growth and protein synthesis and is involved in the modulation of calcium-dependent immune processes. Upregulation of N1,N12-acetylspermine has been linked to the incidence of cancer, making this natural polyamine a potential biomarker for cancer detection.