Abemaciclib Metabolites M2 是 abemaciclib 的代谢物，为有效的 CDK4 和 CDK6 抑制剂，IC50 值为 1-3 nM。具有抗肿瘤活性。
CAS：1231930-57-6
分子式：C25H28F2N8
分子量：478.54
纯度：98%
存储：Store at -20°C

Background:

Abemaciclib Metabolites M2 is a metabolite of abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s in the range of 1-3 nM. Anti-cancer activity[1]. CDK4|1-3 nM (IC50)|CDK6|1-3 nM (IC50)

[1]. Teresa Burke, et al. Abstract 2830: The major human metabolites of abemaciclib are inhibitors of CDK4 and CDK6. Cancer Research. July 2016, 76 (14).