PCI-33380是布鲁顿酪氨酸激酶(BTK)的不可逆抑制剂(荧光探针)。
CAS：1022899-36-0
分子式：C46H52BF2N11O3
分子量：855.78
纯度：98%
存储：Store at -20°C

Background:

PCI-33380 is an irreversible Bruton’s Tyrosine Kinase (BTK) inhibitor (fluorescent probe).

[1]. Zuo Y, et al. A novel 2,5-diaminopyrimidine-based affinity probe for Bruton’s tyrosine kinase. Sci Rep. 2015 Nov 4;5:16136. [2]. Honigberg LA, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80.