Tirabrutinib(ONO-4059)是高选择性，可口服的BTK抑制剂，IC50为2.2nM。
CAS：1351636-18-4
分子式：C25H22N6O3
分子量：454.48
纯度：98%
存储：Store at -20°C

Background:

Tirabrutinib (ONO-4059) is a highly selective, orally bioavailable BTK inhibitor with an IC50 of 2.2 nM.

[1]. Burger JA. Bruton’s tyrosine kinase (BTK) inhibitors in clinical trials. Curr Hematol Malig Rep, 2014 Mar, 9(1):44-9. [2]. Harriet S. Walter et al. A phase 1 clinical trial of the selective BTK inhibitor ONO/GS-4059 in relapsed and refractory mature B-cell malignancies. Blood, 2016 Jan 28, 127(4): 411-419.