TH5487 是一种有效的 8-氧鸟嘌呤 DNA 糖基化酶1 (OGG1) 抑制剂，IC50 为342 nM，TH5487 阻止 OGG1 识别其 DNA 底物，抑制 DNA 修复和修饰 OGG1 染色质动力学，从而抑制促炎基因。
CAS：2304947-71-3
分子式：C19H18BrIN4O2
分子量：541.18
纯度：98%
存储：Store at -20°C

Background:

TH5487 is a potent 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor with an IC50 of 342 nM. TH5487 stops OGG1 from recognizing its DNA substrate, inhibits DNA repair and modifies OGG1 chromatin dynamics, which results in the inhibition of proinflammatory pathway genes[1].

TH5487 (5 μM; 1 hour) decreases TNFα- and LPS-induced proinflammatory gene expression to near pretreatment levels[1].TH5487 (0-10 μM; 1 hour) perturbs binding of NF-κB to 8-oxoG-containing synthetic DNA in nuclear extracts from MLE 12 or hSAEC cells[1]. RT-PCR[1] Cell Line: Murine airway epithelial cell line (MLE 12); Diploid human small-airway epithelial cell (hSAECs)

TH5487 (prophylactic intraperitoneally injection; 8-30 mg/kg; 1-9 hours) decreases TNFα or LPS induced the robust recruitment of neutrophils to the airways, and reduces the pulmonary neutrophil count in a time-dependent manner[1]. Animal Model: Eightweek-old female and male BALB/c mice[1]

[1]. Visnes T, et al. Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation. Science. 2018 Nov 16;362(6416):834-839.