HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM.
CAS：1417997-93-3
分子式：C22H19NO3
分子量：345.39
纯度：98%
存储：Store at -20°C

Background:

HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM.

HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. HDAC8-IN-1 (compound 22 d) shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5); HDAC8-IN-1 exhibits cytotoxicity against human lung CL1-5 cells without significant cytotoxicity for normal IMR-90 cells[1].

参考文献:
[1]. Huang WJ, et al. Synthesis and biological evaluation of ortho-aryl N-hydroxycinnamides as potent histone deacetylase (HDAC) 8 isoform-selective inhibitors. ChemMedChem. 2012 Oct;7(10):1815-24.