Cirsimaritin可以较弱的靶向结合GABAA受体上的苯二氮平位点，并拥有抗抑郁、抗焦虑、抗接种等活性。
CAS：6601-62-3
分子式：C17H14O6
分子量：314.29
纯度：98%
存储：Store at -20°C

Background:

Cirsimaritin binds weakly to the benzodiazepine site on GABAA receptors, with antidepressant, anxiolytic and antinociceptive activities.

Cirsimaritin significantly reduces the anxiety in mice. Cirsimaritin does not decrease by co-administration of flumazenil (2.5 mg/kg) with salvigenin, rosmanol and cirsimaritin (10 mg/kg), indicating that the high-affinity benzodiazepine binding site is not involved in the anxiolytic activity induced by these compounds[1].

[1]. Abdelhalim A, et al. Antidepressant, Anxiolytic and Antinociceptive Activities of Constituents from Rosmarinus Officinalis. J Pharm Pharm Sci. 2015;18(4):448-59.