DM1-SMe is an analog of mertansine with a thiomethane cap attached to the sulfhydryl group.
CAS：138148-68-2
分子式：C36H50ClN3O10S2
分子量：784.4
纯度：98%
存储：Store at -20°C

Background:

DM1-SMe is an analog of mertansine with a thiomethane cap attached to the sulfhydryl group. It has in vitro activity against the pediatric preclinical testing program (PPTP) panel of cancer cell lines with IC50 values of 0.002 to >3 nM.

参考文献:

[1]. Wood, A.C., Maris, J.M., Gorlick, R., et al. Initial testing (Stage 1) of the antibody-maytansinoid conjugate, IMGN901 (Lorvotuzumab mertansine), by the pediatric preclinical testing program Pediatr. Blood Cancer 60(11), 1860-1867 (2013).