Pitavastatin lactone is a major phase 2 metabolite of pitavastatin, an inhibitor of HMG-CoA reductase, that is found in plasma of rats and humans following oral administration.
CAS：141750-63-2
分子式：C25H22FNO3
分子量：403.5
纯度：98%
存储：Store at -20°C

Background:

Pitavastatin lactone is a major phase 2 metabolite of pitavastatin , an inhibitor of HMG-CoA reductase, that is found in plasma of rats and humans following oral administration., Pitavastatin lactone is formed when pitavastatin undergoes glucuronidation by the UDP-glucuronysyl transferases UGT1A1, UGT1A3, or UGT2B7 to form pitavastatin glucuronide, which then undergoes non-enzymatic conversion to pitavastatin lactone. It can be converted back to pitavastatin via hydrolysis.