生物活性
CPI-613是合成的α-硫辛酸硫辛酸类似物的对映异构体的外消旋混合物，具有潜在的化学预防和抗肿瘤活性。
靶点信息
| PDH (NCI-H460 cells) | α-ketoglutarate dehydrogenase (NCI-H460 cells) | | | |
| | | | |
化学数据
| 目录号 | A11786 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 388.6 |
| Formula | C22H28O2S2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 95809-78-2 |
| Synonyms | CPI613 |
| SMILES | C1=CC=C(C=C1)CSCCC(CCCCC(=O)O)SCC2=CC=CC=C2 |
溶解度
| In vitro (25°C) | DMSO | 74 mg/mL (190.43 mM) |
| Water | Insoluble |
| Ethanol | 74 mg/mL (190.43 mM) |
| In vivo | 2% DMSO+corn oil | 13 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 25.73 mL | 128.67 mL | 257.33 mL |
| 0.5 mM | 5.15 mL | 25.73 mL | 51.47 mL |
| 1 mM | 2.57 mL | 12.87 mL | 25.73 mL |
| 5 mM | 0.51 mL | 2.57 mL | 5.15 mL |
*The above data is based on the productmolecular weight 388.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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