Bictegravir是一种新型，有效的HIV-1整合酶抑制剂，其IC50值为7.5nM。
CAS：1611493-60-7
分子式：C21H18F3N3O5
分子量：449.38
纯度：98%
存储：Store at -20°C

Background:

Bictegravir is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.

Bictegravir (BIC) inhibits the strand transfer activity with an IC50 of 7.5± 0.3 nM. Relative to its inhibition of strand transfer activity, Bictegravir is a much weaker inhibitor of 3′-processing activity of HIV-1 IN, with an IC50 of 241±51 nM. Bictegravir enhances the accumulation of 2-LTR circles