生物活性
Asunaprevir是病毒酶丝氨酸蛋白酶NS3的抑制剂。
化学数据
| 目录号 | A11295 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 748.3 |
| Formula | C35H46ClN5O9S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 630420-16-5 |
| Synonyms | BMS650032, ASV |
| SMILES | O=C(N[C@@]1(C(NS(C2CC2)(=O)=O)=O)[C@H](C=C)C1)[C@H]3N(C([C@H](C(C)(C)C)NC(OC(C)(C)C)=O)=O)C[C@@H](OC4=C(C=C(Cl)C=C5)C5=C(OC)C=N4)C3 |
溶解度
| In vitro | DMSO | 89 mg/mL (118.93 mM) |
| Water | Insoluble |
| Ethanol | 89 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 13.36 mL | 66.82 mL | 133.64 mL |
| 0.5 mM | 2.67 mL | 13.36 mL | 26.73 mL |
| 1 mM | 1.34 mL | 6.68 mL | 13.36 mL |
| 5 mM | 0.27 mL | 1.34 mL | 2.67 mL |
*The above data is based on the productmolecular weight 748.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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