生物活性
CCT128930是一种具有ATP竞争性的AKT抑制剂，是一种有效的高级吡咯并嘧啶铅化合物，相对于PKA表现出对AKT的选择性，可通过靶向单个氨基酸差异实现。
靶点信息
| Akt2 (Cell-free assay) | p70 S6K (Cell-free assay) | PKA (Cell-free assay) | | |
| 6 nM | 120 nM | 168 nM | | |
化学数据
| 目录号 | A11031 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 341.8 |
| Formula | C18H20ClN5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 885499-61-6 |
| Synonyms | CCT-128930 |
| SMILES | C1CN(CCC1(CC2=CC=C(C=C2)Cl)N)C3=NC=NC4=C3C=CN4 |
溶解度
| In vitro (25°C) | DMSO | 59 mg/mL (172.59 mM) |
| Water | Insoluble |
| Ethanol | 5 mg/mL (14.63 mM) |
| In vivo | 2% DMSO+30% PEG 300+2% Tween 80+ddH2O | 3 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 29.26 mL | 146.28 mL | 292.57 mL |
| 0.5 mM | 5.85 mL | 29.26 mL | 58.51 mL |
| 1 mM | 2.93 mL | 14.63 mL | 29.26 mL |
| 5 mM | 0.59 mL | 2.93 mL | 5.85 mL |
*The above data is based on the productmolecular weight 341.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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