生物活性
Tipifarnib (Zarnestra)是一种法尼基转移酶抑制剂，可在激酶途径变得过度活跃之前的翻译后修饰步骤中抑制Ras激酶。
靶点信息
化学数据
| 目录号 | A10935 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 489.4 |
| Formula | C27H22Cl2N4O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 192185-72-1 |
| Synonyms | IND 58359, R115777 |
| SMILES | CN1C=NC=C1[C@@](C2=CC=C(C=C2)Cl)(C3=CC4=C(C=C3)N(C(=O)C=C4C5=CC(=CC=C5)Cl)C)N |
溶解度
| In vitro (25°C) | DMSO | 14 mg/mL (28.6 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
| In vivo | 15% Captisol+citrate vehicle | 4 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 20.43 mL | 102.17 mL | 204.33 mL |
| 0.5 mM | 4.09 mL | 20.43 mL | 40.87 mL |
| 1 mM | 2.04 mL | 10.22 mL | 20.43 mL |
| 5 mM | 0.41 mL | 2.04 mL | 4.09 mL |
*The above data is based on the productmolecular weight 489.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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