| CAS NO: | 80434-82-8 |
| 规格: | 98% |
| 分子量: | 366.5 |
| 包装 | 价格(元) |
| 25ug | 电议 |
| 50ug | 电议 |
| 100ug | 电议 |
Background:
20-carboxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. The resulting 20-hydroxy LTB4 is further oxidized to 20-carboxy LTB4. LTB4 metabolism in isolated rat hepatocytes also results in production of 20-carboxy LTB4 along with other ω-oxidation products. The biological activity of 20-carboxy LTB4 is only about 2.6% compared to that of LTB4 in causing PMNL degranulation.
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